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首页> 外文期刊>Pediatric dermatology >Improvement of atopic dermatitis and reduction of skin allergic responses by oral intake of konjac ceramide.
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Improvement of atopic dermatitis and reduction of skin allergic responses by oral intake of konjac ceramide.

机译:口服魔芋神经酰胺可改善特应性皮炎并减少皮肤过敏反应。

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摘要

Although topical application of ceramide is effective in the treatment of atopic dermatitis, its effect is transient. Thus, the effect of oral intake of ceramide on atopic dermatitis was studied. Two groups of 25 children with moderate atopic dermatitis, who were allergic to house dust mite took either milk sugar (control group) or 1.8 mg/day of konjac ceramide in milk sugar (ceramide group) once a day for 2 weeks. Before and after 2 weeks, skin symptoms were assessed using the SCORAD index, while allergic skin responses to house dust mite were assessed by skin prick test. Moreover, production of allergen-specific IgE and various cytokines by mononuclear cells was measured. After 2 weeks, SCORAD index score, allergic skin responses to house dust mite and house dust mite-specific IgE production were significantly reduced in the ceramide group, but not in the control group. Moreover, house dust mite-induced cytokine production was skewed towards the Th1 type, since production of Th1 cytokine, IFN-gamma, and IL-12, was increased, while production of Th2 cytokine, IL-4, and IL-13, was decreased. In contrast, no change of these parameters was found in control group. Collectively, oral intake of konjac ceramide improved skin symptoms and reduced allergic responses with concomitant skewing of the cytokine pattern towards the Th1 type.
机译:尽管局部应用神经酰胺可有效治疗特应性皮炎,但其作用是短暂的。因此,研究了口服摄入神经酰胺对特应性皮炎的影响。两组25例对屋尘螨过敏的中度特应性皮炎儿童,每天两次服用牛奶糖(对照组)或每天1.8 mg /天的魔芋神经酰胺/牛奶糖(神经酰胺组),持续2周。在2周之前和之后,使用SCORAD指数评估皮肤症状,同时通过皮肤点刺试验评估对屋尘螨的过敏性皮肤反应。此外,测量了单核细胞产生的过敏原特异性IgE和各种细胞因子。 2周后,神经酰胺组的SCORAD指数评分,对屋尘螨的过敏性皮肤反应和屋尘螨特异性IgE的产生显着降低,而对照组则没有。此外,屋尘螨诱导的细胞因子产生偏向Th1型,因为Th1细胞因子,IFN-γ和IL-12的产生增加了,而Th2细胞因子,IL-4和IL-13的产生却增加了。减少了。相反,对照组中这些参数没有变化。总体上,口服摄入魔芋神经酰胺可改善皮肤症状并减少过敏反应,并伴随着细胞因子模式向Th1型的倾斜。

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