A One-pot Synthesis of 6-Isopropyl-7-methoxy-1-tetralone and 6-Isopropyl-7-methoxy-2-tetralone

摘要

6-Isopropropyl-7-methoxy-1-tetralone (2) and 6-isopropyl-7-methoxy-2-tetralone (4) have been claimed to be potential intermediates for the synthesis of natural products related to diterpenes miltlrone (5) and carnosic acid (6), respectively. Miltirone, a tanshinone (ortho-quinone diterpene), isolated from S. miltiorrhiza and other species, has previously been synthesized and is cytotoxic against a number of cultured tumor cell lines. Carnosic acid, a naturally occurring catechol-type polyphenols diterpene, is obtained from Rosmarinus officinalis (rosemary) leaves and has also been synthesized previously.9'10 Carnosic acid is known to possess potent anti-oxidant activity as well as anti-cancer and anti-viral properties.