LC-MS analysis in the e-beam and gamma radiolysis of metoprolol tartrate in aqueous solution:Structure elucidation and formation mechanism of radiolytic products

摘要

E-beam and gamma products from the radiolysis of aqueous solutions of (+-)-metoprolol tartrate,saturated in nitrogen,are analyzed by HPLC with on-line mass and UV detectors.The structures of 10 radiolytic products common to e-beam and gamma irradiations are elucidated by comparing their fragmentation pattern to that of (+-)-metoprolol.Two of the radiolytic products are also metabolites.Different routes for the formation of the radiolytic products are proposed.