Flow injection potentiometric determination of amitriptyline hydrochloride

摘要

New plastic membrane electrodes for amitriptyline hydrochloride (AmCl) based on amitriptylinium phosphotungstate (Am-PTA); amitriptylinium phosphomolybdate (Am-PMA) and a mixture of both (Am-PTA/PMA) were prepared. The electrodes were fully characterized in terms of their composition, life span, pH and temperature and then were applied to the potentiometric determination of the amitriptylinium ion in its pure state and pharmaceutical preparations in batch and flow injection conditions. The selectivity of the electrodes towards many inorganic cations, sugars and amino acids was also tested. (C) 2004 Elsevier B.V. All rights reserved.