Will heartburn break your leg?

摘要

A variety of medications can adversely influence the risk of osteoporosis and fractures. Some are well known, with cortico-steroid use being a common cause of osteoporosis whilst heparin treatment for example is a rare cause. An association between the use of antacid medications and an increased fracture risk was reported in 2006 [1 ]. Since then, the use of proton pump inhibitors (PPIs), which are now widely used for the self-medication of dyspepsia, has been associated with an increased risk of fractures, and particularly hip fractures, in a number of studies. This resulted in the issuing of a warning by the US drug regulatory authorities in 2010. The association between PPI use and hip fracture has now been investigated in the Nurses Health Study [2]. Almost 80,000 postmenopausal women were followed for a 6 year period, with data collected on anthropometric and lifestyle factors, on medication use, and on self-reported hip fracture.