(1S,2S)-1-Methylamino-1-phenyl-2-chloropropane: Route specific marker impurity of methamphetamine synthesized from ephedrine via chloroephedrine

摘要

Identification of route specific marker impurities of (. S)-(+)-methamphetamine can provide us with very useful information for (. S)-(+)-methamphetamine abuse criminal investigation. (1. S,2. S)-(+)-Chloropseudoephedrine and (1. R,2. S)-(-)-chloroephedrine are well known impurities of (. S)-(+)-methamphetamine synthesized by metal catalyzed hydrogenation of (1. R,2. S)-(-)-ephedrine or (1. S,2. S)-(+)-pseudoephedrine. In this report (1. S,2. S)-1-methylamino-1-phenyl-2-chloropropane is identified as a route specific marker impurity from metal catalyzed hydrogenation method for the synthesis of (1. R,2. S)-(-)-ephedrine or (1. S,2. S)-(+)-pseudoephedrine . via its chloro-derivative. (1. S,2. S)-1-Methylamino-1-phenyl-2-chloropropane is a ring-opening compound of . cis-1,2-dimethyl-3-phenylaziridine by reacting with HCl in high temperature condition of GC inlet.