Regulation of insulin secretion by geniposide: possible involvement of phosphatidylinositol 3-phosphate kinase

摘要

AIM: Type 2 diabetes mellitus is characterized by lack of, or relative deficiency in, insulin productions and insensitivity of target tissues to insulin. Improvement of beta-cell functions is a potential strategy for the clinical management of this disease. We reported before that geniposide improved glucose-stimulated insulin secretion with the activation of glucagon-like peptide 1 receptor (GLP-1R) in INS-1 pancreatic beta cells, but the cell signaling mechanism of geniposide regulating glucose-stimulated insulin secretion (GSIS) in beta cells is so far poorly understood.