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首页> 外文期刊>European journal of nutrition >The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis.
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The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis.

机译：橄榄叶提取物的抗动脉粥样硬化作用与实验性动脉粥样硬化兔子的炎症反应抑制有关。

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The anti-atherogenic effect of olive leaf extract is supposed to be related to its activities of anti-oxidation and anti-inflammation. AIM OF THE STUDY: To prove the effect of anti-atherosclerosis by olive leaf extract (OLE) and to elucidate the mechanism behind. METHODS: Twenty-four rabbits were assigned to the control, high lipid diet (HLD) and OLE group that were fed with standard diet, HLD and HLD supplemented with OLE, respectively. Serum levels of atherosclerosis related markers, triglyceride (TG), total cholesterol (T-CHO), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and malondialdehyde (MDA) were detected at the ends of week 2, 4 and 6. Surface lesions and thickness of intimas were measured at the end of week6. The protein and/or mRNA expressions of inflammation factors, monocyte chemoattractant protein (MCP)-1, vascular cell adhesion molecule (VCAM)-1, nuclear factor-kappa B (NF-kappaB) and tumor necrosis factor alpha (TNF-alpha) were investigated by immunohistochemistry and RT-PCR. RESULTS: Atherosclerotic lesions were found in the HLD and OLE groups but not in the control group. In comparison with that in the HLD group, reduced size and thickness of intima (0.31 +/- 0.26 in the HLD group versus 0.10 +/- 0.03 mm in the OLE group) were found in the OLE group. The MDA level, an indicator of antioxidant status, was 35.27 +/- 15.37 in the HLD group and 20.63 +/- 11.52 nmol/ml in the OLE group. The level of CHO, TG and LDL-C were 104.46 +/- 30.34, 2.48 +/- 1.11, 82.83 +/- 28.44 mmol/l in the HLD group versus 83.03 +/- 27.23, 1.84 +/- 0.44, 59.51 +/- 23.72 mmol/l in the OLE group. Down-regulated expressions of MCP-1, VCAM-1, NF-kappaB and TNF-alpha at both protein and mRNA level (P 0.05) were also found with the administration of OLE. CONCLUSION: This study proved the effect of OLE on inhibition of atherosclerosis, which is related to the suppressed inflammatory response.
机译：橄榄叶提取物的抗动脉粥样硬化作用可能与其抗氧化和抗炎活性有关。研究目的：证明橄榄叶提取物（OLE）的抗动脉粥样硬化作用，并阐明其背后的机制。方法：24只大白兔分别为对照组，高脂饮食（HLD）和OLE组，分别饲喂标准饮食，HLD和HLD补充OLE。血清的动脉粥样硬化相关标志物，甘油三酸酯（TG），总胆固醇（T-CHO），低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C）和丙二醛（MDA）的水平在在第2、4和6周时，在第6周末测量表面病变和结膜厚度。炎症因子，单核细胞趋化蛋白（MCP）-1，血管细胞粘附分子（VCAM）-1，核因子-κB（NF-kappaB）和肿瘤坏死因子α（TNF-alpha）的蛋白质和/或mRNA表达通过免疫组织化学和RT-PCR研究。结果：HLD和OLE组发现动脉粥样硬化病变，而对照组则没有。与HLD组相比，OLE组发现内膜的大小和厚度减小（HLD组为0.31 +/- 0.26 mm，OLE组为0.10 +/- 0.03 mm）。 MDA水平是抗氧化剂状态的指标，HLD组为35.27 +/- 15.37 nmole，OLE组为20.63 +/- 11.52 nmol / ml。 HLD组的CHO，TG和LDL-C水平为104.46 +/- 30.34、2.48 +/- 1.11、82.83 +/- 28.44 mmol / l，而83.03 +/- 27.23、1.84 +/- 0.44、59.51 + OLE组为23.72 mmol / l。在服用OLE的同时，还发现MCP-1，VCAM-1，NF-κB和TNF-α在蛋白和mRNA水平下调（P <0.05）。结论：本研究证明OLE具有抑制动脉粥样硬化的作用，这与抑制炎症反应有关。

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