First clinical trial of specific I-KACh blocker shows no reduction in atrial fibrillation burden in patients with paroxysmal atrial fibrillation: pacemaker assessment of BMS 914392 in patients with paroxysmal atrial fibrillation

Podd Steven J.; Freemantle Nicholas; Furniss Stephen S.; Sulke Neil

首页> 外文期刊>Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology >First clinical trial of specific I-KACh blocker shows no reduction in atrial fibrillation burden in patients with paroxysmal atrial fibrillation: pacemaker assessment of BMS 914392 in patients with paroxysmal atrial fibrillation

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First clinical trial of specific I-KACh blocker shows no reduction in atrial fibrillation burden in patients with paroxysmal atrial fibrillation: pacemaker assessment of BMS 914392 in patients with paroxysmal atrial fibrillation

机译：特定的I-KACh阻滞剂的首次临床试验表明，阵发性心房颤动患者的房颤负担没有减少：阵发性心房颤动患者的BMS 914392起搏器评估

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Aims To assess the efficacy of BMS 914392 on atrial fibrillation (AF) burden reduction in 20 patients with pacemakers and paroxysmal atrial fibrillation (PAF). BMS 914392 is a potent, selective, oral inhibitor of the I-KACh current and has been shown to suppress AF, whilst having no effect on the ventricular refractory period. This is the first efficacy study of BMS 914392 in patients with PAF.

机译：目的评估BMS 914392在20例起搏器和阵发性房颤（PAF）患者中减少房颤（AF）负担的疗效。 BMS 914392是一种有效的，选择性的I-KACh电流的口服抑制剂，已显示出抑制AF的作用，而对心室不应期没有影响。这是BMS 914392对PAF患者的首次疗效研究。

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《Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology》 |2016年第3期|共7页
作者
Podd Steven J.; Freemantle Nicholas; Furniss Stephen S.; Sulke Neil;
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正文语种 eng
中图分类内科学;
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Paroxysmal atrial fibrillation; Pacemaker monitoring; AF burden; I-KACh current; Anti-arrhythmic drugs; Atrial-specific antiarrhythmic drugs;

机译：阵发性房颤;起搏器监测;房颤负荷;I-KACh电流;抗心律失常药;心房特异性抗心律失常药;

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1. First clinical trial of specific I-KACh blocker shows no reduction in atrial fibrillation burden in patients with paroxysmal atrial fibrillation: pacemaker assessment of BMS 914392 in patients with paroxysmal atrial fibrillation [J] . Podd Steven J., Freemantle Nicholas, Furniss Stephen S., Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology . 2016,第3期

机译：特定的I-KACh阻滞剂的首次临床试验表明，阵发性心房颤动患者的房颤负担没有减少：阵发性心房颤动患者的BMS 914392起搏器评估
2. Stroke type and severity in patients with subclinical atrial fibrillation: An analysis from the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) [J] . Kanjana S. Perera, Mukul Sharma, Stuart J. Connolly, The American heart journal . 2018,第期

机译：亚临床心房颤动患者中风型和严重程度：起搏器患者无症状心房颤动和中风评价的分析及心房颤动降低心房起搏试验（断言）
3. Echocardiographic predictors of frequency of paroxysmal atrial fibrillation (AF) and its progression to persistent AF in hypertensive patients with paroxysmal AF: Results from the Japanese Rhythm Management Trial II for Atrial Fibrillation (J-RHYTHM II Study) [J] . SuzukiT., YamazakiT., OgawaS., Heart rhythm: the official journal of the Heart Rhythm Society . 2011,第12期

机译：超声心动图预测阵发性房颤的高血压患者阵发性心房颤动（AF）的频率及其向持续性房颤的进展：日本房颤的心律管理试验II（J-RHYTHM II研究）
4. Study on How Catheter Ablation Affects Atrial Structures in Patients with Paroxysmal Atrial Fibrillation: The Case of the Coronary Sinus [C] . Aikaterini Vraka, Vicente Bertomeu-González, Joaquín Osca, E-Health and Bioengineering Conference . 2020

机译：导管消融如何影响阵发性心房颤动患者心房结构的研究：冠状动脉窦的情况
5. A Meta-Analysis on the Clinical Effectiveness of Cryoballoon Versus Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation [D] . Lam, Kai Kwan Jeff 2019

机译：阵发性心房颤动患者冷冻球囊与射频消融术临床疗效的Meta分析
6. Left atrial enlargement and non-paroxysmal atrial fibrillation as risk factors for left atrial thrombus/spontaneous Echo contrast in patients with atrial fibrillation and low CHA2DS2-VASc score [O] . Wei-Dong Lin, Yu-Mei Xue, Fang-Zhou Liu, 2020

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First clinical trial of specific I-KACh blocker shows no reduction in atrial fibrillation burden in patients with paroxysmal atrial fibrillation: pacemaker assessment of BMS 914392 in patients with paroxysmal atrial fibrillation

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