Adenosine: a fundamental factor formed from Fatty feasts for fighting fits?

摘要

Adenosine is a purine nucleoside that modulates many physiologic processes, playing pivotal roles in biochemical pathways, signal transduction cascades, and inhibitory neuro-transmission, and it even mediates cellular protection in the CNS. Two primary receptors bind adenosine, the ubiquitous inhibitory adenosine A1 receptor (A_1R), and the less abundant excitatory A_(2A)Rs.The most recognizable role of adenosine is that involving the stimulant caffeine, which counteracts the inhibitory effects of adenosine. Due to its broad inhibitory action, adenosine has long been thought of as an endogenous anticonvulsant, and hence enhancement of purinergic activity would be expected to counter seizure activity (1).