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首页> 外文期刊>Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases >Toll-like receptor 8 (TLR8) polymorphisms are associated with non-progression of chronic hepatitis C in HIV/HCV coinfected patients
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Toll-like receptor 8 (TLR8) polymorphisms are associated with non-progression of chronic hepatitis C in HIV/HCV coinfected patients

机译：Toll样受体8（TLR8）多态性与HIV / HCV合并感染的慢性丙型肝炎未进展有关

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Toll-like receptor 8 (TLR8) polymorphisms have been related to hepatitis C virus (HCV) infection. The aim was to estimate the association of TLR8 polymorphisms with HCV-related outcomes in HIV/HCV coinfected patients. We performed a cross-sectional study of 220 patients who underwent a liver biopsy. TLR8 polymorphisms were genotyped using GoldenGate (R) assay. The outcome variables were non-fibrosis (F0), mild-inflammation (A0/A1), and non-steatosis [fatty hepatocytes (FH) 10%]. Logistic regression analysis was used to compare the outcome variables according to TLR8 polymorphisms. Four polymorphisms were analyzed (rs1013151, rs5744069, rs17256081 and rs3764880rs1013151). Female patients had higher frequency of TLR8 major alleles at rs17256081 and rs101315, and minor alleles at rs3764880 and rs5744069. Male patients had higher frequency of TLR8 minor alleles except for rs3764880, where major alleles were higher (p 0.01). Two TLR8 polymorphisms (rs1013151 and rs5744069) were significantly associated with non-fibrosis (F0) [adjusted odds ratio (aOR) = 4.42 (95% of confidence interval (95% CI) = 1.54; 12.68) (p = 0.006) and aOR = 4.76 (95% CI = 1.69; 13.37) (p = 0.003); respectively]. When data were stratified by gender, rs1013151 and rs5744069 polymorphisms remained significant for male patients [adjusted odds ratio (aOR) = 4.49 (95% CI = 1.08; 18.62) (p = 0.039) and aOR = 6.17 (95% CI = 1.45; 26.20) (p = 0.014); respectively]. When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR = 5.79 (95% CI = 1.44; 23.32) (p = 0.013) and aOR = 8.01 (95% CI = 2.16; 35.65) (p = 0.005); respectively]. Finally, none of the TLR8 polymorphisms were significantly associated with mild-inflammation or non-steatosis. In conclusion, TLR8 polymorphisms seem to be related to non-progression of liver fibrosis in HIV/HCV coinfected patients, particularly in males and those patients infected with GT1. (C) 2015 Elsevier B.V. All rights reserved.
机译：Toll样受体8（TLR8）多态性已与丙型肝炎病毒（HCV）感染有关。目的是评估HIV / HCV合并感染患者中TLR8多态性与HCV相关结局的关系。我们对220例行肝活检的患者进行了横断面研究。使用GoldenGate（R）分析对TLR8多态性进行基因分型。结果变量为非纤维化（F0），轻度炎症（A0 / A1）和非脂肪变性[脂肪肝细胞（FH）<10％]。使用逻辑回归分析根据TLR8多态性比较结果变量。分析了四个多态性（rs1013151，rs5744069，rs17256081和rs3764880rs1013151）。女性患者在rs17256081和rs101315处具有较高的TLR8主要等位基因频率，在rs3764880和rs5744069处具有次要等位基因频率。男性患者具有较高的TLR8次要等位基因频率，但主要等位基因较高的rs3764880除外（p <0.01）。两种TLR8多态性（rs1013151和rs5744069）与非纤维化（F0）显着相关[调整后的优势比（aOR）= 4.42（95％的置信区间（95％CI）= 1.54; 12.68）（p = 0.006）和aOR = 4.76（95％CI = 1.69; 13.37）（p = 0.003）;分别]。当按性别对数据进行分层时，男性患者的rs1013151和rs5744069多态性仍然很显着[校正比值比（aOR）= 4.49（95％CI = 1.08; 18.62）（p = 0.039）和aOR = 6.17（95％CI = 1.45; 26.20）（p = 0.014）;分别]。当按主要HCV基因型对数据进行分层时，感染HCV基因型1（GT1）的患者的rs1013151和rs5744069多态性均具有显着值[aOR = 5.79（95％CI = 1.44; 23.32）（p = 0.013）和aOR = 8.01（ 95％CI = 2.16; 35.65）（p = 0.005）;分别]。最后，TLR8多态性均与轻度炎症或非脂肪变性显着相关。总之，在HIV / HCV合并感染的患者中，TLR8多态性似乎与肝纤维化的进展无关，尤其是在男性和那些感染了GT1的患者中。 （C）2015 Elsevier B.V.保留所有权利。

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