Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010-2011 epidemic season

摘要

Molecular genetic and antigenic features of influenza A/H3N2 virus strains isolated in Western Siberia in 2011 are similar to those of the vaccine strain A/Perth/16/2009 despite a number of unique amino-acid changes. The strains lack specific amino-acid changes in NA protein providing decrease of sensibility to NA inhibitors activity that used in medical practice. Based on phylogenic analysis of HA protein amino-acid sequences examined strains are similar to influenza A/H3N2 virus strains circulatingat the moment in Eurasia.