BEHAVIOURAL STUDY OF CYCLODEXTRIN INCLUSION COMPLI ON ENHANCEMENT OF SOLUBILITY OF ACECLOFENAC

摘要

The main objective of the present study was to enhance the solubility and dissolution rate of poorly water soluble aceclofenac using its solid dispersion with p-cyclodextrin. FTIR and DSC study was carried out to find out any incompatibility. The phase solubility of drug was carried out in 1, 2, 5, and 10% of beta-cyclodextrin in distilled water. Kneading method and solvent evaporation method was use to prepared solid dispersion of aceclofenac and p-cyclodextrin. Different evaluation tests like solubility study in different solvents, PXRD and in vitro dissolution study of aceclofenac- p-cyclodextrin inclusion complex were carried out. The overall finding indicated that p-cyclodextrin is a desirable water soluble carrier, that helps in increasing solubility of drug. Due to its structural feature, p-cyclodextrin forms a good inclusion complex that decreases contact angle of drug with water molecules by increasing wetting properties. Hence, it can be concluded that, p-cyclodextrin is better water soluble carrier molecule in terms of its compatibility and increasing solubility behavior of poorly water soluble drug aceclofenac.