Synthesis and antimicrobial activity of novel 3,10-di-3-methyl-5-[(E)-2-aryl-1 ethenyl]-4-isoxazolyl-4,9-diaryl,2,3,4,9,10,11-hexahydro[1,3] oxazino[6',5':3,4]naphmo[1,2-e][1,3]oxazines

摘要

Synthesis of novel bis-(isoxazolyl-l,3-oxazine)naphthalenes have been accomplished by utilizing Betti base as synthon. The key synthon, Betti base has been synthesized by reaction of isoxazole amine, aromatic aldehyde and 2,3-dihydoxy naphthalene in ethanol. The bis-(isoxazolyl-l,3-oxazine)naphthalenes have been screened for their antimicrobial activity.