Reply to Ikegame et al.

摘要

Ikegame et al. reported a case of idiopathic thrombocyto-penic purpura (ITP) in a BMT recipient and attributed this complication to influenza vaccination. However, this association should be interpreted with caution since several factors, as mentioned by the authors, have been linked to the occurrence of ITP, which is still called 'idiopathic' because the cause remains uncertain.In the normal population and in other high-risk groups, side effects of influenza vaccination are generally mild and observed up to 48 h of vaccination.(soreness at the vaccination site) can affect 10-64% of the subjects but rarely interfere with daily activities.1 Systemic reactions like fever, malaise, myalgia, headache, etc, are less frequent. Recent placebo-controlled studies including persons with asthma,2 the elderly3 and healthy young adults4 did not show higher rates of systemic reactions among vaccinated in comparison to the placebo group. Non-controlled studies have reported systemic reactions in 10-25% of the patients.