Successful cord blood transplantation in a minor BCR-ABL+ CML patient who had been in lymphoid blast crisis at presentation.

摘要

Most CML patients have major bcr-abl (M-bcr) transcripts but a small minority possessing exclusively a minor bcr-abl (m-bcr) transcript has been described.1-2 Only five of the 1384 CML patients (0.36%) in the extensive study by Ravandi et al. were m-bcr~+. So far, 23 cases of CML with m-bcr transcripts have been reported in the literature. Among these, there are only three case reports of blast crisis (BC) at presentation. A GVL effect may contribute to the long-term remission of M-bcr CML patients after allogeneic stem cell transplantation (allo-SCT).4 However, whether a GVL effect can also be contrived in m-bcr~+ CML remains unclear. Here, we describe a patient with m-bcr~+ CML, who was diagnosed as havirig had lymphoid BC of m-bcr~+ CML at presentation, and underwent cord blood transplantation (CBT), resulting in long-term molecular remission. This is the first report of successful CBT for m-bcr~+ CML.