Investigating Protein Structure and Dynamics by Hydrogen Exchange MS

摘要

Thorough characterization of a protein requires understanding the interplay of three separate but linked features—function, structure, and dynamics. Investigating these features demands a wide range of analytical techniques. For example, characterizing protein function, which is the identification of a protein's role in cellular maintenance, is usually more amenable to biochemical, molecular, and cellular types of analyses. On the other hand, studies of protein structure and dynamics most often use physical methods, many of which are common to analytical chemistry.