A method of obtaining large blood collections from Guinea pigs via the saphenous vessel

摘要

Guinea pigs are often overlooked in antibody and vaccine studies due to the difficulty in obtaining reasonable blood samples and quite often the need for cardiac puncture with recovery in order to obtain a pre-bleed reference sample. At the University of Cambridge we have developed some subtle but highly effective refinements that have alleviated these issues meaning no further cardiac punctures being required and maximum sample legal volumes being attained.