Biological evaluation of substituted quinolines.

Franck X; Fournet A; Prina E; Mahieux R; Hocquemiller R; Figadere B

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Biological evaluation of substituted quinolines.

机译：取代喹啉的生物学评价。

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摘要

Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 microM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs.

机译：在体外合成几个喹啉，对几个寄生虫（Trypanosoma Brucei，T.Cruzi，Leishmania Infantum，L.Amazonensis，疟原虫疟原虫）进行评估。然后，在体外（10微米）评估它们，对抗HTLV-1转化细胞。其中一些展示了有趣的活动，与参考药物相当。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2004年第14期|共4页
作者
Franck X; Fournet A; Prina E; Mahieux R; Hocquemiller R; Figadere B;
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作者单位

Laboratoire de Pharmacognosie (associe au CNRS-BioCIS) Faculte de Pharmacie Universite de Paris-Sud rue J.B. Clement 92296 Chatenay-Malabry France.;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Quinolines; Evaluation; Biologic; In Vitro; parasitic; 喹啉类;

机译：Quinolines;Evaluation;Biologic;In Vitro;parasitic;喹啉类;

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Biological evaluation of substituted quinolines.

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