Antiretroviral therapy to prevent transmission in HIV-discordant couples

摘要

Rates of HIV transmission are at least three times lower in HIV-discordant couples in which the partner with infection is receiving antiretroviral therapy, compared with HIV-discordant couples in which the partner with infection is not receiving therapy. Among HIV-discordant couples in which the infected partner has a CD4 cell count of 350 to 550 per mm3 (0.35 to 0.55 x 109 per L), evidence suggests that treating the infected partner with antiretroviral drugs confers a statistically significant decrease in the risk of transmission to the uninfected partner. (Strength of Recommendation: A, based on consistent, good-quality patient-oriented evidence.)