An Exceedingly Mild, Green Synthesis of Substituted NN ‐3‐diaryl‐1,8‐naphthyridin‐2‐amine Derivatives and Their Antimicrobial Activity

摘要

> An exceedingly and highly efficient procedure has been described for the synthesis of substituted N ‐3‐diaryl‐1,8‐naphthyridin‐2‐amines by the reaction of 2‐chloro‐3‐aryl‐1,8‐naphthyridines with various anilines in the presence of N ‐methyl‐2‐pyrrolidone and K ₂ CO ₃ under thermal green solvent‐free conditions. The significant features of this green reaction include very good yields in purity, simple experimental, short reaction time, easy workability, and avoidance of toxic solvents. All synthesized compounds have been evaluated for their antibacterial activity.