Synthesis and Antimicrobial Activity of 2‐(4‐(Hydroxyalkyl)‐1 HH ‐1,2,3‐triazol‐1‐yl)‐ NN ‐substituted propanamides

摘要

> A series of 21 2‐(4‐(hydroxyalkyl)‐1 H ‐1,2,3‐triazol‐1‐yl)‐ N ‐substituted propanamides (1,4‐disubstituted 1,2,3‐triazoles having amide linkage and hydroxyl group) have been synthesized from click reaction between terminal alkyne and 2‐azido‐ N ‐substituted propanamide (generated in situ from reaction of 2‐bromo‐ N ‐substituted propanamide and sodium azide) and characterized by FTIR, 1 H NMR, 13 C NMR spectroscopy, and HRMS. All the newly synthesized triazoles were tested in vitro for antimicrobial activity against four bacterial cultures – Escherichia coli , Enterobacter aerogenes , Klebsiella pneumoniae , and Staphylococcus aureus – and two fungal cultures – Candida albicans and Aspergillus niger . The synthesized 1,4‐disubstituted 1,2,3‐triazoles displayed moderate to good antimicrobial potential against the tested strains.