Synthesis of 3,3-bis(2-haloethyl) and 3,3,3'-tris(2-haloethyl) derivatives of 1,1'-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides)

摘要

Synthetic procedures towards 3,3-bis(2-haloethyl) and 3,3,3'-tris(2-haloethyl) derivatives of 1,1'-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides) via halogenation of the corresponding 2-hydroxyethyl derivatives of 1,1'-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides) and iodination of the corresponding 2-bromoethyl derivatives were elaborated. The synthesized compounds are promising NO donors in the living organisms.