Molecular imprinting on surface of silica particles for the selective extraction of benzylparaben in flow system applied to cosmetics and water samples

摘要

Molecular imprinted polymer coated Silica (Si-MIP) particles were prepared using non-covalent approach. The Si-MIP material was employed as selective solid phase extraction sorbent for the determination of benzylparaben (BP) in samples of environmental and cosmetic origin. The preconcentration step was studied firstly in a batch system and subsequently it was optimized and adapted to an automatized flow system and the eluate was then analyzed by HPLC-UV. The whole procedure was validated, showing satisfactory analytical parameters. The methodology was applied to real samples showing extraction recoveries always better than 98.85%. A linear response within the concentration range of 1.11 x 10(-5)-0.025 mg mL(-1) was obtained for BP (r(2) = 0.9998). The limits of detection and quantification after Si-MIP-HPLC procedure were 3.34 and 11.16 ng mL(-1), respectively. The developed methodology provided a simple an economic way for accomplishing a clean-up/preconcentration step and the subsequent determination of BP in a complex matrix. The showed selectivity plus robustness and the possibility of reutilization, enable it to be used for BP routine monitoring in personal care products (PCP) and environmental samples.