Beat-to-beat sensitivity analysis of human systemic circulation coupled with the left ventricle model of the heart: A simulation-based study

摘要

.Model-based simulations are widely used to study the dynamics of the cardiovascular system. More importantly, model-based simulations have flexibility to run virtual simulations to know the behavior of hemodynamics in different realistic scenarios. Within this work, a lumped-parameter model of left ventricle (LV) is coupled with the complete systemic circulation (SC). Where, different heart rates are fed into the heart model and their impact are studied in a patient having different levels of aortic abnormalities (stenoses, aneurysms). For this purpose, global sensitivity analysis was used to quantify the impact of aortic abnormalities in the SC in complement with different heart rates. Moreover, simulation-based study is an important tool for medical doctors, students and teachers to enhance their understanding of hemodynamics in healthy and diseased states of vessels, as well as to identify the best possible measurement locations for pressure and flow to detect aortic abnormalities in the SC.