Inhibitors of zinc-dependent metalloproteinases (MMP-2 and MMP-9) in the series of benzoylamino (phenylsulfonyl) -substituted cyclic amino acids as potential drugs that prevent postinfarction remodeling of the left ventricle of the heart

摘要

FIELD: biotechnology.SUBSTANCE: benzoilamino (phenylsulfonyl)-substituted cyclic amino acids of the general formulawhere R, R, R, R, R, R, Rmay be hydrogens, halogen atoms, (C-C)-alkyl groups, nitro groups; "n" can be 1-3, and their physiologically acceptable salts which are inhibitors of zinc-dependent metalloproteinases (MMP-2 and MMP-9). Also a method for preparation of compounds of formula (1) and a method for treating by remodelling of the left ventricle of the heart in the peracute phase of myocardial infarction using compounds of the formula (1) are provided.EFFECT: increased efficiency of treatment.4 cl, 3 dwg, 2 tbl, 3 ex