A Trivariate Weibull Model For Effects of Drospirenone and Estrogen in Postmenopausal Women with Hypertension

摘要

The usage of weibull distribution is wide in parametric analysis of failure time data. The simple form of the weibull survivor function is an attractive property for right-censored observation which occurs frequently in survival studies. The corresponding hazard rate which increases, constant or decrease according to the value of one parameter. This behavior is commonly accepted as appropriate in many situation. In the application part, Drospirenone (DRSP), a progestin with antialdosterone activity, had been developed for hormone therapy in combination with 17-β-estradiol (E2) in postmenopausal women. The antihypertensive efficacy and safety of various doses of DRSP and E2 and estradiol alone in postmenopausal women with hypertension using ambulatory and clinic blood pressure (BP) monitoring is evaluated. In conclusion the mathematical model we constructed support the medical result that DRSP combined with E2 significantly reduces BP in postmenopausal women with hypertension and did not induce significant increases in serum potassium. These characteristics may lead to a new benefit for this novel hormone therapy in postmenopausal women with hypertension.