EFFECTS OF ESTROGEN ON PULMOMARY VASCULAR REMODELING IN PULMONARY ARTERY HYPERTENSION

摘要

This study shows that estrogen limits pulmonary vascular function changes during the development of mild PAH, consistent with prior animal studies, which demonstrated that estrogen attenuated pulmonary vascular structure changes via histology. The novel finding in our study is that estrogen preserves PA compliance with little effect on tPVR in mild PAH. This differential effect of estrogen on proximal and distal PA remodeling may have an impact on RV adaptive remodeling in PAH. To shed additional light on the estrogen paradox, future studies on the roles of estrogen in both PA and RV remodeling in severe PAH are warranted.