THYMOL AND EUGENOL LOADED CHITOSAN DENTAL FILM FOR TREATMENT OF PERIODONTITIS

摘要

The main objective of this study was to formulate an intrapocket chitosan (CS) dental film loaded with thymol (TH) and eugenol (EU) for the treatment of periodontal diseases. The antibacterial and antifungal efficacy of TH (5ug/mL) measured in terms of zone of inhibition against S. mutans was 10±2mm and against C. albicans was 10±4mm. The zone of inhibition measured for EU (5ug/mL) was 2.1±3mm against S.mutans and 3±2mm for C. albicans. The minimum inhibitory concentration of TH and EU was found to be in the range of 100-150ug/mL against both S. mutans and C. albicans. For the local delivery of TH and EU, the CS films were prepared by solvent casting method and evaluated for various physicochemical parameters and in vitro antibacterial activity. The film showed good physicochemical properties. The study suggests that CS dental film containing TH and EU is a potential drug delivery device for the topical treatment of periodontal disease.