A monoclonal antibody against CD86 and its protection in a murine lupus nephritis model of chronic graft-versus-host disease

Han Lianhua; Shen Lijun; Zhu Ying; Qiu Yuhua

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A monoclonal antibody against CD86 and its protection in a murine lupus nephritis model of chronic graft-versus-host disease

机译：针对CD86的单克隆抗体及其在慢性移植物与宿主病的鼠狼肾炎模型中的保护

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Context: Lupus nephritis is the most common complication that causes the death of systemic lupus erythematosus patients. CD28/CTLA4 and their ligands CD80 or CD86 costimulatory pathway play a pivotal role in autoimmune disease and organ transplantation.

机译：背景：狼疮性肾炎是最常见的并发症，导致系统性红斑狼疮患者死亡。 CD28 / CTLA4及其配体CD80或CD86共刺激途径在自身免疫疾病和器官移植中起着枢轴作用。

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来源
《Immunopharmacology and immunotoxicology》 |2017年第6期|共7页
作者
Han Lianhua; Shen Lijun; Zhu Ying; Qiu Yuhua;
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作者单位

Soochow Univ Affiliated Hosp 1 Dept Cardiol Suzhou Jiangsu Peoples R China;

Soochow Univ Inst Biol Suzhou Jiangsu Peoples R China;

Soochow Univ Affiliated Hosp 1 Dept Clin Lab Suzhou Jiangsu Peoples R China;

Soochow Univ Med Coll Dept Immunol Suzhou 215123 Jiangsu Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Anti-human CD86 antibody; lupus nephritis; chronic graft-versus-host disease; costimulatory molecules; systemic lupus erythematosus;

机译：抗人CD86抗体;狼疮性肾炎;慢性接枝 - 与宿主病;刺激性分子;系统性狼疮红斑狼疮;

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专利

1. A monoclonal antibody against CD86 and its protection in a murine lupus nephritis model of chronic graft-versus-host disease [J] . Han Lianhua, Shen Lijun, Zhu Ying, Immunopharmacology and immunotoxicology . 2017,第1a6期

机译：针对CD86的单克隆抗体及其在慢性移植物与宿主病的鼠狼肾炎模型中的保护
2. Preferential Blockade of CD8+ T Cell Responses by Administration of Anti-CD137 Ligand Monoclonal Antibody Results in Differential Effect on Development of Murine Acute and Chronic Graft-Versus-Host Diseases [J] . Kazuhisa Nozawa, Junko Ohata, Jinkyo Sakurai, The journal of immunology . 2001,第9期

机译：通过给予抗CD137配体单克隆抗体的CD8 + T细胞应答的优先阻断导致对小鼠急性和慢性移植物抗宿主病的发展产生不同的影响。
3. Treatment of a murine model of human lupus with a monoclonal antibody that blocks binding of C3d to its receptors decreases anti-DNA autoantibodies and proteinuria: Implications for the CR2:C3d interaction as a therapeutic target in lupus and other autoimmune diseases [J] . Holers V. Michael, Laskowski Jennifer, Thurman Joshua M., Immunobiology: Zeitschrift fur Immunitatsforschung . 2016,第10期

机译：用能阻断C3d与其受体结合的单克隆抗体治疗人狼疮的鼠模型，可降低抗DNA自身抗体和蛋白尿：CR2：C3d相互作用作为狼疮和其他自身免疫性疾病的治疗靶标的意义
4. The multiplexed analysis of two therapeutic monoclonal antibodies and non-murine IgG in a pharmacological mouse model by LC-MS/MS [C] . Mark Jairaj, Lloyd King, Ted Parton American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：通过LC-MS / MS的药理学小鼠模型中两种治疗单克隆抗体和非鼠IgG的复用分析
5. Characterization of Anti-Ricin Monoclonal Antibodies and the Construction of a Chimeric Murine-Human IgG2/K Anti-Ricin Monoclonal Antibody [D] . Vendramelli, Robert Matthew 2011

机译：抗蓖麻毒蛋白单克隆抗体的表征和鼠/人IgG2 / K嵌合抗蓖麻毒蛋白单克隆抗体的构建
6. Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft-versus-host disease [O] . Takanori Kuroiwa, Tsuyoshi Iwasaki, Takehito Imado, 2006

机译：肝细胞生长因子预防慢性移植物抗宿主病的鼠科狼疮模型中的狼疮肾炎
7. Pathogenesis of experimental lupus nephritis: a role foranti-basement membrane and anti-tubular brush border antibodiesin murine chronic graft-versus-host disease [O] . J. A. BRUIJN, P. C. W. HOGENDOORN, W. E. CORVER, 2008

机译：实验性狼疮性肾炎的发病机制：弃药角色膜和抗管刷边界抗体抗体蛋白慢性移植物 - 宿主病
8. Mouse Monoclonal Antibody Specific for an Allotypic Determinant of the Igh(a) Allele of Murine IgM: Genetic and Functional Analysis of Igh-6a Epitopes Using Anti-IgM Monoclonal Antibodies. [R] . Sieckmann, D. G., Stall, A. M., Subbarao, B. 1991

机译：小鼠单克隆抗体特异性针对Igh（a）小鼠Igm等位基因的同种型决定因素：使用抗Igm单克隆抗体的Igh-6a表位的遗传和功能分析。

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A monoclonal antibody against CD86 and its protection in a murine lupus nephritis model of chronic graft-versus-host disease

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