Dirhodium(II)-Catalyzed Cyclopropanation of Alkyne-Containing alpha-Diazoacetates for the Synthesis of Cycloalkynes

摘要

An efficient dirhodium(II)-catalyzed macrocyclization reaction of alkyne-containing diazoacetates through intramolecular metal carbene cyclopropanation is described. This method provides a variety of 12- to 22-membered macrocyclic alkynes, which incorporate ortho-aryl, cyclopropane, and cyclopropene units, in good to excellent yields under mild reaction conditions.