Advanced Drug Delivery Systems for Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs: A Review

摘要

Background: Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs(NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption,and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). Transdermalroute is also beneficial for drugs having a narrow therapeutic index. The skin acts as the primary barrierfor transdermal delivery of various therapeutic molecules.Various advanced nanocarrier systems offer several advantages like improved dermal penetration alongwith an extended drug release profile due to their smaller size and high surface area. Various nanocarriersexplored for transdermal delivery of NSAIDs are liposomes, niosomes, ethosomes, polymericnanoparticles (NPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), dendrimers,nanosuspensions/nanoemulsion, and nanofibers.Objectives: In the present review, our major aim was to explore the therapeutic potential of advancednanocarrier systems enlisted above for transdermal delivery of NSAIDs. All literature search regardingadvanced nanocarrier systems for transdermal delivery of NSAIDs was done using Google Scholar andPubmed.Conclusions: Advanced nanocarriers have shown various advantages like reduced side effect, low dosingfrequency, high skin permeation, and ease of application over conventional transdermal deliverysystems of NSAIDs in various preclinical studies. However, clinical exploration of advanced nanocarriersystems for transdermal delivery of NSAIDs is still a challenge.