Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor preventive microenvironment in intestinal epithelial Pten-deficient mice

摘要

Phosphatase and tensin homolog (Pten) antagonizes PI3K-Akt signaling; therefore, Pten impairment causes tumorigenesis. However, the correlation between Pten deficiency and colon cancer has remained elusive due to numerous opposite observations. To study this correlation, we examined whether Pten deficiency in intestinal epithelial cells (IECs) induces tumorigenesis.