To study the antimicrobial drug long-term drug effects on mice intestinal microbiomediversity,this paper selected in April 2015 ~ April 2016 of the experimental mice a center as the research object, continuous dosing 15 d, berberine, ciprofloxacin and metronidazole, to respectively analyze the change of the gut microbes in mice group.The results showed that the team of intestinal flora in mice abundance and all degrees were lower than the control group, which reduced the highest proportion of metronidazole, followed by berberine, finally to ciprofloxacin; The effect of ciprofloxacin and metronidazole on the high abundance of OTUs in the intestinal flora of mice was larger, but the effect on the low abundance OTUs was small. It followed that the antimicrobial drugs for a long time to give medicine in mice intestinal microbiome diversity had a certain influence, metronidazole influence was most obvious.%为探讨抗微生物药长期给药对小鼠肠道微生物组多样性的影响，选取2015年4月-2016年4月某中心提供的实验小鼠为研究对象，连续给药15d，分别为黄连素、环丙沙星与甲硝唑，分析小鼠肠道微生物组的变化。结果表明：研究组小鼠肠道菌群丰度与均度均低于对照组，其中降低比重最高的为甲硝唑，其次为黄连素，最后为环丙沙星；环丙沙星与甲硝唑对小鼠肠道菌群结构高丰度OTUs影响较大，而对低丰度OTUs影响较小。由此得出，抗微生物药长期给药对小鼠肠道微生物组多样性有一定的影响，其中甲硝唑影响最为明显。
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