Rapid desensitization of humanized mice with anti-human Fc epsilon RI alpha monoclonal antibodies

摘要

Background: Anaphylaxis is classically mediated by allergen cross-linking of IgE bound to the alpha chain of Fc epsilon RI, the mast cell/basophil high affinity IgE receptor. Allergen cross-linking of the IgE/Fc epsilon RI complex activates these cells, inducing release of disease-causing mediators, cytokines, and enzymes. We previously demonstrated that IgE-mediated anaphylaxis could be safely prevented in wild-type BALB/c mice by rapid desensitization with anti-mouse Fc epsilon RI alpha mAb.