Development and characterization of DNAzyme candidates demonstrating significant efficiency against human rhinoviruses

Potaczek Daniel P.; Unger Sebastian D.; Zhang Nan; Taka Styliani; Michel Sven; Akdag Nesibe; Lan Feng; Helfer Markus; Hudemann Christoph; Eickmann Markus; Skevaki Chrysanthi; Megremis Spyridon; Sadewasser Anne; Alhamwe Bilal Alashkar; Alhamdan Fahd; Akdis Mubeccel; Edwards Michael R.; Johnston Sebastian L.; Akdis Cezmi A.; Becker Stephan; Bachert Claus; Papadopoulos Nikolaos G.; Garn Holger; Renz Harald

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Development and characterization of DNAzyme candidates demonstrating significant efficiency against human rhinoviruses

机译：DNAzyme候选人的发展与鉴定探讨了人鼻病毒的显着效率

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Background: Infections with human rhinoviruses (RVs) are responsible for millions of common cold episodes and the majority of asthma exacerbations, especially in childhood. No drugs specifically targeting RVs are available.

机译：背景：对人鼻病毒（RVS）的感染负责数百万常见的感冒情集和大多数哮喘恶化，特别是在儿童时期。没有专门针对RV的药物。

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来源
《The Journal of Allergy and Clinical Immunology》 |2019年第4期|共13页
作者
Potaczek Daniel P.; Unger Sebastian D.; Zhang Nan; Taka Styliani; Michel Sven; Akdag Nesibe; Lan Feng; Helfer Markus; Hudemann Christoph; Eickmann Markus; Skevaki Chrysanthi; Megremis Spyridon; Sadewasser Anne; Alhamwe Bilal Alashkar; Alhamdan Fahd; Akdis Mubeccel; Edwards Michael R.; Johnston Sebastian L.; Akdis Cezmi A.; Becker Stephan; Bachert Claus; Papadopoulos Nikolaos G.; Garn Holger; Renz Harald;
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作者单位

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

PreDicta Consortium Marburg Germany;

PreDicta Consortium Marburg Germany;

Secarna Pharmaceut GmbH Planegg Germany;

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

PreDicta Consortium Marburg Germany;

Secarna Pharmaceut GmbH Planegg Germany;

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

Philipps Univ Marburg Inst Virol Marburg Germany;

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

PreDicta Consortium Marburg Germany;

Secarna Pharmaceut GmbH Planegg Germany;

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

PreDicta Consortium Marburg Germany;

PreDicta Consortium Marburg Germany;

PreDicta Consortium Marburg Germany;

PreDicta Consortium Marburg Germany;

Philipps Univ Marburg Inst Virol Marburg Germany;

PreDicta Consortium Marburg Germany;

PreDicta Consortium Marburg Germany;

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

UGMLC German Ctr Lung Res DZL Inst Lab Med Giessen Germany;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Allergy; antisense; antiviral; asthma; atopy; DNAzyme; exacerbation; human rhinovirus; RNA; therapy;

机译：过敏;反义;抗病毒;哮喘;特性;DNazyme;恶化;人鼻病毒;RNA;治疗;

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专利

1. Development and characterization of DNAzyme candidates demonstrating significant efficiency against human rhinoviruses [J] . Potaczek Daniel P., Unger Sebastian D., Zhang Nan, The Journal of Allergy and Clinical Immunology . 2019,第4期

机译：DNAzyme候选人的发展与鉴定探讨了人鼻病毒的显着效率
2. Development of a RT Real-Time PCR for the Detection and Quantification of Human Rhinoviruses [J] . Stefano Gambarino, Cristina Costa, Mariateresa Elia, Molecular Biotechnology . 2009,第3期

机译：RT实时PCR的检测和定量人类鼻病毒的发展。
3. Development of a RT Real-Time PCR for the Detection and Quantification of Human Rhinoviruses [J] . Gambarino S, Costa C, Elia M, Molecular biotechnology . 2009,第3期

机译：RT实时PCR的检测和定量人类鼻病毒的发展。
4. Characterization of Human Growth Hormone for the Development of Candidate Reference Material [C] . Youxun Jin, Yong-Hyeon Yim, Sook-Kyung Kim, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：候选参考资料发展人体生长激素的特征
5. Extraction, Purification and Characterization of a Pure Peptide from Soybean to Demonstrate Anti-Proliferation Activity on Human Cancer Cells and Test the Ability of Soy Peptide Fractions in Reducing the Activity of Angiotensin-I Converting Enzyme. [D] . Rayaprolu, Srinivas. 2015

机译：从大豆中提取，纯化和鉴定纯肽以证明其对人癌细胞的抗增殖活性，并测试大豆肽级分降低血管紧张素-I转化酶活性的能力。
6. Biologic and Genetic Characterization of a Panel of 60 Human Immunodeficiency Virus Type 1 Isolates Representing Clades A B C D CRF01_AE and CRF02_AG for the Development and Assessment of Candidate Vaccines [O] . Bruce K. Brown, Janice M. Darden, Sodsai Tovanabutra, 2005

机译：一组60种人类免疫缺陷病毒1型分离株的生物学和遗传学表征分别代表进化枝ABCDCRF01_AE和CRF02_AG用于开发和评估候选疫苗
7. Biologic and Genetic Characterization of a Panel of 60 Human Immunodeficiency Virus Type 1 Isolates, Representing Clades A, B, C, D, CRF01_AE, and CRF02_AG, for the Development and Assessment of Candidate Vaccines [O] . Brown, Bruce K., Darden, Janice M., Tovanabutra, Sodsai, 2005

机译：一组60种人类免疫缺陷病毒1型分离株的生物学和遗传学表征，分别代表进化枝A，B，C，D，CRF01_AE和CRF02_AG，用于开发和评估候选疫苗

Development and characterization of DNAzyme candidates demonstrating significant efficiency against human rhinoviruses

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