Enantio- and Diastereoselective Cyclopropanation of beta,gamma-Unsaturated alpha-Ketoester by a Chiral Phosphate/Indium(III) Complex

摘要

We report herein an enantioselective cyclo-propanation of beta,gamma-unsaturated alpha-ketoesters with diazoesters by the complexes of InBr3 and, Chiral calcitim phosphates The reaction proceeds via a Michael addition-Cyclization pathway to afford highly functionalized chiral Cyclopropanes with excellent enantioselectivities (up to >99% ee) as a single diastereoisomet.