Addition of caffeine to cell suspension in production of chiral beta-hydroxy esters by stereoselective microbial reduction of prochiraler alpha substituted beta-ketoester using whole-cell biotransformation, increases diastereoselectivity

摘要

In the production of chiral beta -hydroxy esters (I) by stereoselective microbial reduction of prochiral alpha -substituted beta -ketoester using whole-cell biotransformation, caffeine is added to increase the diastereoselectivity of the microbial reduction of the cell suspension.