Diffusion-weighted imaging (DWI) is an MRI technique that yields unique information regarding the movement of water molecules at the cellular level. Now widely available and rapid to perform the sequence is increasingly utilized within abdominopelvic oncology, including anorectal cancer imaging. Unfortunately, the diffusion properties of anorectal tumors are complex and not fully understood, with areas of cellular tumor, necrosis and fibrosis co-existing. While DWI shows promise both for staging and in assessing treatment response in anorectal cancer, there remains a lack of consensus regarding its role and integration into standard MRI protocols. This article outlines the basic science behind DWI and reviews the current evidence base for its use in anorectal cancer.
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