Multimodality therapy for malignant pleural mesothelioma: surgery plus chemoradiotherapy?

摘要

Malignant pleural mesothelioma, well known for its association with asbestos exposure, is an aggressive cancer of the pleura with poor prognosis if left untreated. There is no defined standard of care, but with curative surgery-based multimodality therapy, long-term survival has been documented. In addition to radiation and/or chemotherapy, multimodality therapy includes one of two operations (extrapleural pneumonectomy or radical pleurectomy/decortication) performed with the goal of resecting all gross disease. Ongoing trials are evaluating various treatment strategies involving radical resection, chemotherapy, radiation, intracavitary chemotherapy, photodynamic therapy and immunologic/biologic agents. Improvement in early diagnosis, targeted treatment and adjuvant therapy to control micrometastatic disease are needed to improve outcomes for patients with this challenging disease.