Synthesis and docking studies of novel quinoline substituted thiobarbituric acid derivatives as potential therapeutic agents for type-II diabetes

摘要

In the present work novel 5-((2-chloroquinolin-3-yl)methylene)-dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione derivatives were synthesized by Knoevenagel condensation of 2-chloroquinoline-3-carbaldehyde with thiobarbituric acid. The synthesized compounds were successfully characterized by FTIR, H-1 NMR and C-13 NMR. Further comparative docking studies were carried out to find out the effective binding affinity of thiobarbituric acid derivatives with Peroxisome Proliferator Activated Receptor-Gamma (PPAR-gamma) and aldose reductase receptors with to that of standard, Rosiglitazone and Epalrestat. The results obtained have clearly shown that 5-((2-chloroquinolin-3-yfimethylene)-dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione possess good binding affinity with PPAR-gamma, aldose reductase receptors on par with the standard.