Esomeprazole 20mg provides more effective intragastric acid control than maintenance-dose rabeprazole,lansoprazole or pantoprazole in healthy volunteers

摘要

Objective: A high proportion of patients with gastro-oesophageal reflux disease experience recurrence of symptoms within a year of initial treatment. The key to preventing relapse is an effective maintenance therapy that maintains intragastric pH >4. This study was conducted to compare the effects on intragastric pH of maintenance doses of four proton pump inhibitors: esomeprazole 20mg, lanso-prazole 15mg, rabeprazole l0mg and pantoprazole 20mg.Study participants and methods: Three standardised, randomised, two-way crossover studies were performed in a total of 108 Helicobacter pylori-negative healthy subjects. Intragastric pH was monitored on day 5 of once-daily oral dosing. The percentage of time of a 24-hour period with intragastric pH >4 and mean 24-hour median pH were measured on day 5.Results: The mean percentage of time with intragastric pH >4 on day 5 was significantly longer following esomeprazole 20mg compared with either lan-soprazole 15mg (esomeprazole 50.4% vs lansoprazole 43.0%, p = 0.026), rabeprazole l0mg (esomeprazole 59.8% vs rabeprazole 51.7%, p = 0.011) or pantoprazole 20mg (esomeprazole 59.6% vs pantoprazole 39.5%, p < 0.0001).Conclusions: Maintenance dose esomeprazole 20mg provided greater acid con trol and maintained intragastric pH >4 for a longer period of time than mainten ance dose lansoprazole 15mg, rabeprazole lOmg and pantoprazole 20mg in healthy subjects.