Tyrosinase Inhibition and Mutagenicity of Phenolic Compounds from Mulbeny Leaves

摘要

The tyrosinase inhibition activity and mutagenicity as assessed by the Ames test on phenolic antioxidants (5-Caffeoyl quinic acid, 3,4-Dihydroxy cinnamic acid, Quercetin 3-O-p-D-glucopyranose, Kaempferol 3-Op-D-glucopyranose) and the ethyl acetate fraction isolated from mulbeny leaves were examined. The ethyl acetate fraction and chlorogenic acid exhibited weaker tyrosinase inhibitory activities than kojic acid. In addition, the ethyl acetate fraction from mulbeny leaves, containing phenolic antioxidants, showed no mutagenicity by the Ames test