Synthesis and DNA studies of a copper(II) complex of 5,6-dihydro-5,6-epoxy-1,10-phenanthroline

摘要

A new copper( II) complex, [ Cu( epoxy)( phen)( NO3)]( NO3) center dot H2O ( epoxy = 5,6- dihydro- 5,6- epoxy1,10- phenanthroline, phen = 1,10- phenanthroline), has been synthesized and characterized by elemental analysis, IR and UV- vis spectroscopy, and single crystal X- ray diffraction. The complex crystallized in a monoclinic system with space group P21/ n, a = 13.3199( 8)angstrom, b = 11.2917( 7)angstrom, c = 16.0832( 9)angstrom, a = 90 degrees, beta = 107.827( 4)degrees, and. = 90 degrees. The complex cation possesses a distorted octahedral geometry, with Jahn- Teller distortion occurring in the CuN4O2 core. The binding interaction with calf thymus DNA ( CT- DNA) was investigated by UV- vis and fluorescence spectroscopy, cyclic voltammetry, and viscometry. The results support a partially intercalative binding mode. Efficient cleavage of plasmid DNA by the complex was observed by gel electrophoresis.