Core/Shell Macrobeads for the Protection of Islets from Immune System Rejection

摘要

Core/shell macrobeads,composed of a hydrogel core and a biodegradable polymeric shell,were designed and evaluated for the protection of islets from both fibrous tissue development as well as the modulation of the immune system rejection response.The core/shell macrobeads(2,000 mum diameter)were prepared with approximately 150 mum thick polymeric shells.Islets isolated from pancreas of C57/BL6 mice were encapsulated in these core/shell macrobeads.The islets-loaded core/shell macrobeads were planted in the peritoneal cavity of diabetes mellitus-induced C57/BL6 mice and the blood glucose concentrations were measured.