Facile Synthesis of Hydantoin Derivatives under Microwave Irradiation

摘要

The rapid and highly efficient synthesis of hydantoin derivatives 3(a-f) was achieved under microwave irradiation by using a domestic microwave oven from the reactions of cyanohydrin derivatives 2(a-f) with ammonium carbonate.The reaction proceeded rapidly (2-5 min.),and as a result a series of hydantoin derivatives 3(a-f) were obtained in high yields.All of the synthesized compounds were fully characterized by their melting point,1H-NMR,FTIR spectroscopy and elemental analyses.Cyanohydrin derivatives 2(a-f) were also prepared from the ketone derivatives l(a-f) with potassium cyanide in the presence of sodium metabisulflte in an additional reaction.