A peptide construct containing B-cell and T-cell epitopes from the foot-and-mouth disease viral VP1 protein induces efficient antiviral protection

摘要

A new peptide construct Palm 135-158-GGA-170-188(Acm) was synthesized and investigated in a number of in vitro and in vivo test systems. The construct contained a virus specific T-helper epitope within the 170-188 sequence of VP1, in addition to themain antigenic 135-158 region of the foot and mouth disease (FMD) viral VP1 protein (strain A22). The construct had higher protective, antigenic, immunogenic and T-cell proliferative activity than the previously described shorter peptide Palm2 135-159.The 170-188 part of the construct serves as a virus specific T-epitope, responsible for improved anti-FMD virus activity.