Three new prenylflavonol glycosides from heat-processed Epimedium koreanum

摘要

Phytochemical investigation of the n-BuOH extract of the leaves of processed Epimedium koreanum led to the isolation of three new prenylflavonol glycosides, epimedkoresides A-C (1-3), along with the 15 known ones (4-18). The structures of the three new compounds were established on the basis of chemical and spectroscopic methods as 8-gamma-hydroxy-gamma,gamma-dimethylpropyl-5,7,4'-trihydroxy-flavonol-3-O-beta-D-glucopyranosyl(1 -> 2)-alpha-L-rhamnopyranoside (1). 8-gamma-hydroxy-gamma,gamma-dimethylpropyl-5,7,4'-trihydroxy-flavonol-3-O-alpha-L-rhamnopyranosyl(1 -> 2)-alpha-L-rhamnopyranoside (2), and anhydroicaritin 3-O-alpha-L-rhamnopyranosyl(1 -> 2)-alpha-L-rhamnopyranosyl-7-O-alpha-Lrhamnopyranosyl(1 -> 2)-beta-D-glucopyranoside (3), respectively. Additionally, partial structures were evaluated for their anti-inflammatory activity.