Increased expression of metalloproteinase-2 and-9 (MMP-2, MMP-9), tissue inhibitor of metalloproteinase-1 and-2 (TIMP-1, TIMP-2), and EMMPRIN (CD147) in multiple myeloma

摘要

Introduction: Activity of metalloproteinases (MMP) is controlled both by specific tissue inhibitors (TIMP) and activators (extracellular matrix metalloproteinase inducer, EMMPRIN). There are few data available concerning concentration the bone marrow of MMP-2, MMP-9, TIMP-1, and TIMP-2, or EMMPRIM expression by bone marrow mesenchymal stromal cells (BMSCs) in patients with multiple myeloma (MM).