Preparation and cytotoxic activity of nickel(II) complexes with 6-benzylaminopurine derivatives

摘要

Nickel(II) complexes with 6-benzylaminopurine (BAP) derivatives, namely 6-(3-chlorobenzylamino)purine (HL_1), 6-(4-chlorobenzylamino)purine (HL_2) and 6-(4-fluorobenzylamino)purine (HL_3), have been prepared and characterized by elemental analyses, i.r., u.v.-v.i.s., ES+ and FAB + mass spectroscopy, magnetic susceptibility and conductivity measurements, and by thermal analysis. The complexes are: [Ni(L_1(H_2O)_2Cl]·H_2O, [Ni(L_1)(H_2O)(NO_3)]·H_2O, [Ni(L_2)(H_2O)_2Cl], [Ni(L_2)(H_2O)_2(NO_3)]·H_2O, [Ni(HL_2)(H_2O)Cl_2]·EtOH and [Ni(L_3)(H_2O)_2Cl]. They have been tested in vitro for their possible cytotoxic activity against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 (human breast adenocarcinoma) cell lines.